This funding opportunity aims to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The initiative will support two collaborative research consortia through open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. The program encourages hypothesis-centered research on interactions between alcohol and other relevant causal influences, particularly focusing on trajectories from initial exposure to pathological drinking, with the goal of identifying translatable markers and mechanisms to facilitate future prevention and intervention of conditions associated with alcohol misuse. Innovation is central, with investigators encouraged to utilize advanced tools from the BRAIN Initiative, NIH Common Fund, and other sources, to analyze brain structure and function at multiple spatial and temporal scales and peripheral influences. The initiative emphasizes integration across biological scales, standardization, replication, collaboration across sites, sharing of resources, standardized protocols, and cross-species translation.
This funding opportunity aims to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The initiative will support two collaborative research consortia through open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. The program encourages hypothesis-centered research on interactions between alcohol and other relevant causal influences, particularly focusing on trajectories from initial exposure to pathological drinking, with the goal of identifying translatable markers and mechanisms to facilitate future prevention and intervention of conditions associated with alcohol misuse. Innovation is central, with investigators encouraged to utilize advanced tools from the BRAIN Initiative, NIH Common Fund, and other sources, to analyze brain structure and function at multiple spatial and temporal scales and peripheral influences. The initiative emphasizes integration across biological scales, standardization, replication, collaboration across sites, sharing of resources, standardized protocols, and cross-species translation.